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Potential Drug-Nutrient Interactions and Known Risk Factors

The long-term use of prescription and over the counter (OTC) drugs can induce subclinical and clinically relevant micronutrient deficiencies. This may develop gradually over months or even years. Nutrient deficiencies seldom present as classically described as they may not be as drastic as a complete deficiency. Thus, many health care providers are not knowledgeable about micronutrient deficiency or excess. This may lead to erroneous attribution of deficiency states to a disease state or the aging process itself and may delay diagnosis. Drug-induced micronutrient depletion may be the origin of otherwise unexplained symptoms, some of which might influence medication compliance.

- Mohn et al., Pharmaceutics 2018 review.

Below are two tables that outline the drug-nutrient interactions causing a deficiency or sometimes, an excess of vitamins and minerals for your reference.

Refer to reference 2 for alternative table and more information.


1) Emily S. Mohn 1, Hua J. Kern 2, Edward Saltzman 1, Susan H. Mitmesser 2 and Diane L. McKay 1,* "Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update."Pharmaceutics 2018,10, 36. doi:10.3390/pharmaceutics10010036

2) Common Drug Classes, Drug-Nutrient Depletions, & Drug-Nutrient Interactions. Pharmavite LLC 2017. <>

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